Mental stress leads to chronic activation of the neuroendocrine systems. Cortisol favors central fat deposition, a decrease in the adipostatic signal leptin and an increase in the orexogenic signal ghrelin, inducing increased appetite and food intake. For women, stress often presents itself more prominently in the stomach. (https://www.ncbi.nlm.nih.gov/
The brain has a direct effect on the stomach and intestines. For example, the very thought of eating can release the stomach's juices before food gets there. This connection goes both ways. A troubled intestine can send signals to the brain, just as a troubled brain can send signals to the gut. This phenomenon contributes to the current obesity epidemic. -
Therefore, a person's stomach or intestinal distress not only creates excess fat storage but can be the cause or the product of anxiety, stress, or depression. That's because the brain and the gastrointestinal (GI) system are intimately connected. (Harvard medical)
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